Saliva levels of caspase-1, TNF-alpha, and IFN-gamma in primary Sjogren's syndrome: oral mucosal abnormalities revisited

WOS: 000435653900016PubMed ID: 29914252Background/aim: Abnormalities in oral mucosal immunity contribute to complex pathogenesis of primary Sjogren's syndrome (pSjS). We aimed to measure saliva and serum levels of caspase-1, tumor necrosis factor-alpha (TNF-alpha) and interferon gamma (IFN-gamma) in patients with pSjS. Materials and methods: We studied 43 pSjS patients fulfilling the AECG criteria and 30 age/sex-matched healthy controls, as well as 39 rheumatoid arthritis (RA) patients as a disease control group. ESSDAI scores were less than seven in all patients with pSjS, indicating low disease activity. Quantitative analyses were made in serum and whole saliva samples. The statistical analysis was performed using SPSS 19.0. Results: While no significant difference was found in serum measurements, saliva levels of TNF-alpha and caspase-1 were significantly higher in pSjS patients versus healthy controls when using the Mann-Whitney U test. On the other hand, in the pSjS group, saliva levels of TNF-alpha and caspase-1 were also significantly higher compared to the RA group using Student's t-test. In the pSjS group, those parameters did not show any correlation with disease duration, seropositivity, and smoking. Conclusion: Despite low disease activity, saliva TNF-alpha and caspase-1 levels were found to be significantly higher in the pSjS group, which may suggest a possible advantage of local anticytokine treatments in selected cases.Research Foundation of Ege University, Izmir, TurkeyEge UniversityA grant from the Research Foundation of Ege University, Izmir, Turkey, supported this study