Anti-inflammatory activity of Anthemis aciphylla var. aciphylla Boiss.

WOS: 000298197800014Ethanolic (EEAA) and sesquiterpene lactone (SEAA) extracts of the aerial parts of Anthemis aciphylla var. aciphylla Boiss. (Asteraceae) were evaluated for anti-inflammatory activity on carrageenin-induced paw edema (acute model) and cotton pellet-induced granuloma (chronic model) in rats. In carrageenin-induced paw edema, EEAA and SEAA at intraperitoneal doses of 50, 100, and 200 mg/kg dose-dependently inhibited the paw edema. In cotton pellet-induced granuloma, the oral administration of EEAA and SEAA at 50, 100, and 200 mg/kg dosages was also found to significantly inhibit granuloma tissue formation.Ege University, Izmir, TurkeyEge University [2008/ECZ/001]This research was supported by Ege University's Research Fund (No. 2008/ECZ/001), Izmir, Turkey