Long-term entecavir or tenofovir disoproxil fumarate therapy in treatment-naïve chronic hepatitis B patients in the real-world setting

Idilman R.
Gunsar F.
Koruk M.
Keskin O.
Meral C.E.
Gulsen M.
Elhan A.H.
Akarca U.S.
Yurdaydin C.

Open link

Publication date

January 2015

DOI

10.1111/jvh.12358

Publisher

Wiley

ISSN

1352-0504

Journal

Journal of Viral Hepatitis

Citation count (estimate)

Abstract

PubMed ID: 25431108Summary The aim of this study was to determine the long-term efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) on the natural course of disease in chronic hepatitis B patients (CHB) with/without cirrhosis in clinical practice. A total of 355 treatment-naïve CHB patients were enrolled into the study. The primary outcome measure was viral suppression as defined by serum HBV DNA level <20 IU/mL. A secondary outcome measure was to determine the development of Hepatocellular carcinoma (HCC). Virological and biochemical responses were similar between the two treatment groups over time. The presence of cirrhosis and hepatitis B e antigen (HBeAg) positivity did not appear to impact viral suppression. The cumulat...