Use of radiopharmaceuticals for imaging hypoxic tissues [Hipoksik dokularin görüntülenmesinde radyofarmasötiklerin klinik kullanimi]

Hypoxia is the state between oxygen absence and normal oxygenation of the healthy tissue and when the oxygen necessity for normal cell function goes beyond the sources, cells respond to this situation by down-regulating their metabolism. This hypoxic condition is observed in various clinically significant diseases primarily cancer. Tumor hypoxia may increase resistance to radiation therapy and to some forms of chemotherapy. That is why detection of hypoxia is important. Radiolabelled nitroimidazoles, misonidazole analogues, iodoazomycin nucleosides are used for imaging hypoxia