The effect of granulocyte colony-stimulating factor on mortality rate in experimental sepsis [DENEYSEL SEPSISTE GRANULOSIT KOLONI-STIMULAN FAKTOR UYGULANMESININ MORTALITEYE ETKISI]

Neutrophils have an important role in the initial phase of host defense. One of the growth factors, Granulocyte Colony-Stimulating Factor (G-CSF) enhances neutrophil counts and functional capacity. The aim of this study was to investigate the effect of recombinant human (rh) G-CSF on mortality rate in an experimental sepsis model performed by 'Cecal Ligation and Puncture' (CLP) in rats. Totally 48 rats were separated into 3 groups and SF alone (Group I) or antibiotic alone (Group II) or antibiotic + G-CSF (Group III) were injected 24 hours before CLP procedure. The calculated absolute neutrophil counts of the blood samples taken by cardiac puncture at the 24th hour after CLP were significantly higher in Group III when compared to the other groups and the control samples which were taken before the study period (p0.05). Further investigations are necessary for G-CSF to be used widely in clinical pratice