Effects of two different doses of dexmedetomidine on intraoperative desflurane consumption, hemodynamic parameters and neuromuscular blockade [İki farkli deksmedetomidin dozunun i·ntraoperatif desfluran tüketimi, hemodinamik parametreler ve kas gevşemesi üzerine olan etkileri]

Purpose: The effects of two different doses of dexmedetomidine, a selective ? 2-receptor agonist, on anesthetic agent consumption and neuromuscular blockade and intraoperative analgesic requirement were aimed to compare with the control group. Material and methods: Sixty patients between 18 and 60 ages were studied. Three groups were made, dexmedetomidine infusion was begun for Group A and Group B, 1 µg kg -1 and 0.5 µg kg -1 respectively and Group C were infused serum physiologic. After the standard anesthesia induction, dexmedetomidine infusion was begun for Group A and Group B, 0.5 µg kg -1h -1 and 0.25 µg kg -1 h -1 respectively and Goup C were infused serum physiologic. During the operation, hemodynamic parameters, neuromuscular function, BIS and total amount of desflurane were recorded. Results: Total desflurane consumptions (Group A: 50.12±15 ml, Group B: 80.26±13.7 ml, Group C:92.19±25.1 ml), additional dose of fentanyl and the onset time of rocuronium in Group A were statistical difference lower than other groups. Conclusion: It was concluded that administration of dexmedetomidine as a bolus of 1µkg -1 and as an infusion dose of 0.5 µkg -1 h -1 decreases the onset time of rocuronium, and decreases desflurane consumption by 45% in accordance with the control group, and reduces intraoperative requirement for additional analgesic dose