Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study

WOS: 000393032300016PubMed ID: 27191365The cross-sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate = 30) was found in 34% of subjects. The lowest nocturnal oxygen saturation was 81 +/- 10.2%. Chronic kidney disease prevalence in the whole sample was 8.7% or 6.1%, according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease-Epidemiology Collaboration equations, respectively. Subjects with lower estimated glomerular filtration rate were older, more obese, more often female, had worse obstructive sleep apnea and more co-morbidities (P < 0.001, each). With both equations, independent predictors of estimated glomerular filtration rate < 60 were: chronic heart failure; female gender; systemic hypertension; older age; higher body mass index; and worse lowest nocturnal oxygen saturation. It was concluded that in obstructive sleep apnea, chronic kidney disease is largely predicted by co-morbidities and anthropometric characteristics. In addition, severe nocturnal hypoxaemia, even for only a small part of the night, may play an important role as a risk factor for kidney dysfunction.Chiesi farmaceutici; Philips Respironics PLC; ResMed PLCThe following authors declare no competing interests: O. Marrone, O. K. Basoglu, J. A. Kvamme, S. Ryan, J. L. Pepin, J. Verbraecken and M. R. Bonsignore. S. Battaglia declares grant/research support from Chiesi farmaceutici. L. Grote declares these potential conflicts of interest: study equipment support from ltamar. Philips and Weinmann; speakers bureau: Weinmann, Resmed, Philips; consultant: Breas. Resmed and Mundipharma. J. Hedner declares speakers bureau from Weinmann, Almirall, Astra-Zeneca, MSD.; Philips Respironics PLC and ResMed PLC provided unrestricted grants to support overall maintenance of the ESADA. They played no role in data collection or analysis, or manuscript preparation, and had no access to data