Genetic polymorphisms of interleukin 1 beta gene and sporadic pancreatic neuroendocrine tumors susceptibility

WOS: 000408543000005PubMed ID: 27326321AIM: To evaluate the association between the inter-leukin 1 beta (IL-1 beta) polymorphisms and the pancreatic neuroendocrine tumor (pNET) development. METHODS: A case-control study was conducted analyzing IL-1 beta polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer (51 pNET cases, 85 pancreatic ductal adenocarcinoma cases, 19 intraductal papillary mucinous neoplasm and 98 healthy controls). RESULTS: The distribution of genotypes for the -511 C/T polymorphism in the pNET patient groups showed significant difference compared to the control group. It is known that the carriers of the IL-1 beta -511T allele have increased concentrations of IL-1 beta. The -511 CT and TT high-expression genotypes were over-represented in pNET patients. CONCLUSION: The findings of this study suggested a possible role of IL-1 beta -511 C/T genotypes in the pathogenesis of pNETs since the presence of the IL-1 beta -511 CT and TT genotypes and the T allele was associated with an increased risk of pNET only.Hellenic Society of Medical Oncology [5839/08-04-2015]Supported by Hellenic Society of Medical Oncology, No. 5839/08-04-2015