Add to ORKGBiopsy specimens of the cerebral cortex from two histologically confirmed cases of Alzheimer's disease were examined by means of electron microscopy. The senile plaques consisted of a complex of abnormal dendrites, axons and extracellularly located amyloid. Alzheimer's neurofibrillary tangles were made of bundles of filaments in the pericaryon. Amyloid in the plaques and in the liver showed the same ultrastructural morphology. A suggestion is made that the changes observed at the synaptic level are possibly responsible for memory defects in the disease. No evidence was found to suggest any viral or vascular aetiology in the disease. (Journal received: 18 January 1977
The deposition of amyloid beta (A beta) protein plays a central role in the neuropathology of Alzhei...
SUMMARY: Histologically identified intracellular and extracellular inclusions and structures often p...
The transentorhinal cortex (TEC) is an obliquely oriented cortex located in the medial temporal lobe...
Histologically Alzheimer's disease is chiefly characterized by senile plaques and neurofibrillary de...
Although forms of dementia arising late in life had been identified by Kraepelin and his colleagues ...
We show how electron microscopy can be used to answer several critical issues in neurodegenerative d...
In this symposium, we review the neuropathology of Alzheimer's disease with emphasis on cerebral cor...
To clarify early pathologic changes in Alzheimer's disease, the brains from two cases from a single ...
Alzheimer's disease (AD) is characterized by extracellular aggregation and deposition of Amyloid-bet...
The thesis was designed to address two major questions about the pathogenesis of Alzheimer's disease...
The cause of the degeneration of nerve cells, and the loss of specific synaptic connections, that u...
The entorhinal cortex (EC) is especially vulnerable in the early stages of Alzheimer's disease (AD)....
The numbers and distribution of the neurofibrillary tangles and neuritic plaques have been determine...
Alzheimer’s disease (AD) is characterized by extracellular aggregation and deposition of Amyloid-bet...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by irreversible ...
The deposition of amyloid beta (A beta) protein plays a central role in the neuropathology of Alzhei...
SUMMARY: Histologically identified intracellular and extracellular inclusions and structures often p...
The transentorhinal cortex (TEC) is an obliquely oriented cortex located in the medial temporal lobe...
Histologically Alzheimer's disease is chiefly characterized by senile plaques and neurofibrillary de...
Although forms of dementia arising late in life had been identified by Kraepelin and his colleagues ...
We show how electron microscopy can be used to answer several critical issues in neurodegenerative d...
In this symposium, we review the neuropathology of Alzheimer's disease with emphasis on cerebral cor...
To clarify early pathologic changes in Alzheimer's disease, the brains from two cases from a single ...
Alzheimer's disease (AD) is characterized by extracellular aggregation and deposition of Amyloid-bet...
The thesis was designed to address two major questions about the pathogenesis of Alzheimer's disease...
The cause of the degeneration of nerve cells, and the loss of specific synaptic connections, that u...
The entorhinal cortex (EC) is especially vulnerable in the early stages of Alzheimer's disease (AD)....
The numbers and distribution of the neurofibrillary tangles and neuritic plaques have been determine...
Alzheimer’s disease (AD) is characterized by extracellular aggregation and deposition of Amyloid-bet...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by irreversible ...
The deposition of amyloid beta (A beta) protein plays a central role in the neuropathology of Alzhei...
SUMMARY: Histologically identified intracellular and extracellular inclusions and structures often p...
The transentorhinal cortex (TEC) is an obliquely oriented cortex located in the medial temporal lobe...