Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)2(NH3)2] and cis-[Pt(tsac)2(NH3)2]
- Al-Jibori S.A.
- Al-Jibori G.H.
- Al-Hayaly L.J.
- Wagner C.
- Schmidt H.
- Timur S.
- Barlas F.B.
- Subasi E.
- Ghosh S.
- Hogarth G.
Publication date
January 2014
DOI Publisher
Elsevier BV Journal
Journal of Inorganic BiochemistryAbstract
PubMed ID: 25216367The new platinum(II) complexes cis-[Pt(sac)2(NH3)2] (sac = saccharinate) and cis-[Pt(tsac)2(NH3)2] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)2(NH3)2].H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. © 2014 Elsevier B.V. All rights reserved
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