The synthesis and anticonvulsant activity of some ?-phthalimido-N- phenylacetamide and propionamide derivatives

PubMed ID: 14981667In this study, by combining anilide and N',N'- phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen ?-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2,6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that ?-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure