Comparison of metamizol and ketorolac tromethamine using continuous infusion in the treatment of postoperative pain [POSTOPERATIF AGRI TEDAVISINDE SUREKLI INFUZYON YONTEMI ILE METAMIZOL VE KETOROLAK TROMETAMININ KARSILASTIRILMASI]

The aim of this study is to compare the postoperative analgesic effects of two non-opioids, ketorolac tromethamine (KT) and metamizol (M), using a continuous infusion method after elective major abdominal surgery. 34 ASA Class I-II patients aged between 21-65 years were divided randomly into two groups. Patients received an initial IV dose of KT 20 mg followed by 3 mg/h continuously in the first group. In the second group, after an initial IV dose of M 500 mg, continuous infusion of 75 mg/h was administered. During the postoperative period, the intensity of pain by visual analog scale, heart rate, systolic and diastolic blood pressure, respiratory rate, transcutaneous oxygen saturation were recorded before the injection and at 1, 3, 6, 12, 24 h. Daily opioid need and side-effects were also determined. At the end of the study, the patients made a final assessment and gave a point for the analgesic method. The two groups were similar with respect to demographic data, duration of surgery and vital signs. Although pain scores were significantly decreased according to baseline values in both groups, there was no statistical difference in VAS scores between the two groups (p>0.05). 4 patients in group KT and 6 patients in group M needed opioids. There was no statistically significant difference between the number of opioid-administered patients and average meperidin doses used (p>0.05). We conclude that ET and M are similar with respect to their effects on analgesic quality and opioid need when they are administered by continuous infusion method