The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers
In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequ...
Metastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated...
The work presented in this thesis demonstrates and explores the unexpected oncogenic role of a previ...
The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cance...
Inositol polyphosphate 4-phosphatase-II (INPP4B) is a regulator of the phosphoinositide 3-kinase (PI...
Triple-negative breast cancer [TNBC, lacks expression of estrogen receptor (ER), progesterone recept...
Triple-negative breast cancer (lacking expression of estrogen receptor, progesterone receptor and am...
Enzymes (PI3K and PTEN) controlling cellular levels of 3-phosphorylated phosphoinositides are known ...
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is co...
The phosphoinositide-3 kinase (PI3K) pathway is deregulated in a significant proportion of melanomas...
SummaryWe report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (...
Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-ki...
Inositol Polyphosphate 4-Phosphatase Type II (INPP4B) was established to play a tumour suppressive r...
Class I phosphoinositide 3-kinase (PI3K) generates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(...
SummaryMetastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) ge...
In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequ...
Metastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated...
The work presented in this thesis demonstrates and explores the unexpected oncogenic role of a previ...
The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cance...
Inositol polyphosphate 4-phosphatase-II (INPP4B) is a regulator of the phosphoinositide 3-kinase (PI...
Triple-negative breast cancer [TNBC, lacks expression of estrogen receptor (ER), progesterone recept...
Triple-negative breast cancer (lacking expression of estrogen receptor, progesterone receptor and am...
Enzymes (PI3K and PTEN) controlling cellular levels of 3-phosphorylated phosphoinositides are known ...
INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is co...
The phosphoinositide-3 kinase (PI3K) pathway is deregulated in a significant proportion of melanomas...
SummaryWe report that knocking down the expression of inositol polyphosphate 4-phosphatase type II (...
Inositol polyphosphate 4-phosphatase type II (INPP4B) negatively regulates phosphatidylinositol 3-ki...
Inositol Polyphosphate 4-Phosphatase Type II (INPP4B) was established to play a tumour suppressive r...
Class I phosphoinositide 3-kinase (PI3K) generates phosphatidylinositol 3,4,5-trisphosphate (PtdIns(...
SummaryMetastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) ge...
In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequ...
Metastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated...
The work presented in this thesis demonstrates and explores the unexpected oncogenic role of a previ...
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