Effect of nifedipine on the collar-induced intimal thickening and vascular reactivity changes in rabbits

The positioning of a soft and nonocclusive silicon collar around the rabbit carotid artery induces intimal thickening and characteristic vascular reactivity changes. In the present study, we investigated whether the treatment with nifedipine, a dihydropyridine derivative calcium channel blocker (CCB) (40 mg/kg/day, p.o.), inhibit development of intimal thickening and accompanying vascular reactivity changes in this model. Neither intimal thickening nor vascular reactivity changes were effected by nifedipine treatment in this model