Evaluation of chitosan/biphasic calcium phosphate scaffolds for maxillofacial bone tissue engineering

Urkmez, Aylin Sendemir
Clark, Sherrie G.
Wheeler, Matthew B.
Goldwasser, Michael S.
Jamison, Russell D.

Open link

Publication date

January 2008

DOI

10.1002/masy.200850912

Publisher

Wiley

ISSN

1022-1360

Journal

Macromolecular Symposia

Citation count (estimate)

Abstract

4th European Symposium on Biopolymers -- OCT 02-04, 2007 -- Kusadasi, TURKEYWOS: 000258909100013Porous, 3D chitosan/biphasic calcium phosphate (BCP) scaffolds were used to prepare tissue engineering constructs for maxillofacial bone tissue reconstruction. Mesenchymal stem cells (MSC's) were seeded and cultured on clinically relevant sized scaffolds. in vitro engineered constructs facilitated the healing of mandibular defects in pigs if accompanied with delivery of basic fibroblast growth factor (bFGF)