GC-MS Investigation and Acetylcholinesterase Inhibitory Activity of Galanthus rizehensis

WOS: 000322090700007PubMed ID: 23819307GC-MS (gas chromatography-mass spectrometry) analyses of alkaloids in the aerial parts and bulbs of Galanthus rizehensis Stern (Amaryllidaceae), collected during two different vegetation periods, was performed. Twenty three alkaloids were identified in four different alkaloid extracts. Acetylcholinesterase (AChE) inhibitory activities of the alkaloid extracts were tested. Both the highest alkaloid diversity and the most potent inhibitory activity (IC50 12.94 mu g/ml) were obtained in extracts from the bulbs of G. rizehensis collected during the fruiting period.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-104T272]; EBILTEMEge University [2007/BIL/007]; Ege University Research FundEge University [09/ECZ/014, 09/ECZ/021]; TUBITAK-BIDEBTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)This study was financially supported by TUBITAK (TBAG-104T272), EBILTEM (2007/BIL/007), Ege University Research Fund (09/ECZ/014, 09/ECZ/021). B. B. S. thanks TUBITAK-BIDEB for a research fellowship. The authors also thank Dr. Asuncion Marin (Serveis Cientificotecnics, Universitat de Barcelona, Facultat de Farmacia, Barcelona, Spain) for performing the GC-MS analyses