Nanobiomaterials for controlled release of drugs and vaccine delivery

2006 Materials Research Society Spring Meeting -- 18 April 2006 through 19 April 2006 -- San Francisco, CA -- 68130A number of natural and synthetic, and biodegradable polymers were investigated and remain to be elucidated for both soft and hard tissue repair, and for possible construction of excipient therapeutic templates. Nonwoven matrices from poly (?-caprolactone) (PCL) homopolymers and poly (L-lactide/e-caprolactone) (PLLA/CL) copolymers by electrospinning process were investigated for possible applications in bum/wound dressings. Efforts are currently underway to control the release characteristics of these biodegradable fibers by varying aliphatic polyesters. This perspective will have a profound effect on the time-controlled transport of vaccine to a targeted site. These materials will play a key role in developing novel chemotherapeutic agents that could be important in targeting specific genes and may provide selective control of gene expression. Furthermore, these fibers-by-design address many issues relating to the fundamental challenges in the synthesis of novel, biocompatible and safe delivery of vaccine and nanofiber materials to foster antibacterial and/or hygienic functionality, System-on-Fibers (SoF), and will have tremendous application in global security and defense. © 2006 Materials Research Society