Alkaloids from Galanthus rizehensis

Two new Amaryllidaceae alkaloid N-oxides, incartine N-oxide (1) and lycorine N-oxide (2) together with one ß-carboline alkaloid, 1-acetyl-ß-carboline (3) and six known alkaloids namely, incartine (4), N-trans feruloyltyramine (5), lycorine (6), O-methylnorbelladine (7), vittatine (8) and 11-hydroxyvittatine (9) were isolated from Galanthus rizehensis Stern (Amaryllidaceae). The structures of the alkaloids were elucidated by spectroscopic analyses (UV, IR, MS, 1D and 2D NMR). Acetylcholinesterase inhibitory activity potentials of the compounds were also determined. © 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.2009-SGR-1060 Generalitat de Catalunya 07/BIL/007 104T272 09/ECZ/021, 09/ECZ/014We thank the Scientific and Technological Research Council of Turkey (TUBITAK, 104T272), Ege Science and Technology Center (EBILTEM, 07/BIL/007), Ege University Research Fund ( 09/ECZ/014 and 09/ECZ/021 ) for their financial support. B.B.S. was a recipient of TUBITAK-BIDEB research fellowship. This work was partially performed within the framework of project 2009-SGR-1060 (Generalitat de Catalunya). -