Diagnostic importance of serological methods and eosinophilia in tissue parasites

WOS: 000181547500012PubMed ID: 12659417This case-control study was carried out to investigate whether eosinophilia is a common finding in parasitic diseases and to determine the prevalence of the parasitic diseases in definitive groups. Toxocariasis and fasciolosis were investigated in patients with eosinophilia, patients with non-eosinophilia, and healthy controls. All cases were analyzed for antibodies against Toxocara canis and Fasciola hepatica by modified enzyme-linked immunosorbent assay (ELISA) employing, as antigen, excretory/secretory products of Toxocara and Fasciola (ES-ELISA). Seropositivity was determined in 39 (29.1%) and 12 (8.9%) toxocariasis and fasciolosis patients with eosinophilia respectively. The seropositivity was found in 26 (19.4%) and 5 (3.7%) toxocariasis and fasciolosis patients without eosinophilia respectively. The seropositivity was found in 13 (15.5%) and 1 (1.2%) toxocariasis and fasciolosis patients in the control group. The total seropositivity in both toxocariasis and fasciolosis in the eosinophilic group (8.5%) increased significantly compared to patients without eosinophilia (23.1%) and healthy controls (6.6%) (chi(2) :6.343, p<0.05 and chi(2): 10.293, p