Patient-controlled sedation and analgesia during SWL

13th World Congress on Endourology and SWL -- NOV, 1995 -- JERUSALEM, ISRAELWOS: A1996VN17900002PubMed ID: 8905484Sixty unpremedicated outpatients undergoing elective extracorporeal shockwave lithotripsy (SWL) using a Dornier MPL 9000 lithotripter were randomly assigned to receive either propofol-alfentanil (PA group; N = 30) or midazolam-alfentanil (MA group; N = 30) by a patient-controlled analgesia (PCA) device for sedation and analgesia, Although pain intensity scores were lower after 20 minutes and sedation was more pronounced in the MA group, both drug regimens produced satisfactory sedation and analgesia and allowed the maximum number of shockwaves to be given, Alfentanil consumption was less in the MA group (P < 0.05), Both groups were hemodynamically stable, The patients in the MA group had slower ventilation rates, lower oxygen saturation, and higher end-tidal carbon dioxide levels, Use of MA was associated with more episodes of oxygen desaturation to < 90% (30% vs, 11%; P < 0.05). One patient in the PA group and three patients in the MA group developed bradypnea (