Effect of lipoic acid on the some elements in brain tissue of DMBA-induced Guinea Pigs [DMBA i·le i·ndüklenmiş kobaylari{dotless}n beyin dokusundaki bazi{dotless} elementler üzerine alfa lipoik asidin etkisi]

The oxidative stress, depending on many factors in the etiology of developing cancer caused by reactive oxygen species, plays an important role. In our study, 7, 12-dimethylbenz-[a]anthracene (DMBA) was applied in Guinea Pigs, the alpha lipoic acid (?-LA) has antioxidant properties was investigated protective role against to levels of macro and trace elements in brain. In experiments; totally 24 adult male Guinea Pigs were randomly divided into 4 equal groups (control, DMBA, ?-LA and DMBA+?-LA) containing same numbers. As a result of the analysis in Guinea Pigs brain with the aid of ICP-AES; it was found that the level of calcium from macro elements in DMBA group increased according to control group (P0.05). As a result, it can be said that from the point of macro and trace elements, the lipoic acid (?-LA) was indicated neuroprotective effect for protection of important organs such as brain from the oxidative stress