Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity

WOS: 000423801700007PubMed: 29323749A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.Turkiye Bilimsel ve Teknolojik Arastirma Kurumu [14Z554]Turkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant number: 14Z55