Catalytic Friedel-Crafts Reactions of Highly Electronically Deactivated Benzylic Alcohols
- Vukovic, Vuk D.
- Richmond, E. (Edward)
- Wolf, E. (Eléna)
- Moran, J. (Joseph)
DOIAbstract
Highly electronically deactivated benzylic alcohols, including those with a CF3 group adjacent to the OH-bearing carbon, undergo dehydrative Friedel–Crafts reactions upon exposure to catalytic Brønsted acid in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) solvent. Titration and kinetic experiments support the involvement of higher order solvent/acid clusters in catalysis
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