BACKGROUND: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More recently large initiatives such as the International Knockout Mouse Consortium (IKMC) are using the C57BL/6N mouse strain to generate null alleles for all mouse genes. Hence both strains are now widely used in mouse genetics studies. Here we perform a comprehensive genomic and phenotypic analysis of the two strains to identify differences that may influence their underlying genetic mechanisms. RESULTS: We undertake genome sequence comparisons of C57BL/6J and C57BL/6N to identify SNPs, indels and structural variants, with a focus on identifying all coding variants. We annotate 34 SNPs ...
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically...
Due to its rapid reproductive cycle, short life span and and genetic and physiological similarity to...
Forward genetics is a powerful approach based on chromosomal mapping of phenotypes and has successfu...
BACKGROUND: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been ...
Abstract Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome h...
Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been ...
Mice are extremely important as the premier model organism in human biomedical and mammalian genetic...
Abstract Background Allelic variation is the cornerstone of genetically determined differences in ge...
In our laboratory, we have focused on the behavioral diversity of wild derived mouse strains. A w...
The C57BL/6J (B6) inbred mouse strain is commonly used in biomedical researches. However, some unexp...
We sequenced the complete genome of the widely used C57L/J mouse inbred strain. With 40× average cov...
Since the turn of the century the complete genome sequence of just one mouse strain, C57BL/6J, has b...
Inbred mouse strains provide the foundation for mouse genetics. By selecting for phenotypic features...
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically...
Reverse genetics methods, particularly the production of gene knockouts and knockins, have revolutio...
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically...
Due to its rapid reproductive cycle, short life span and and genetic and physiological similarity to...
Forward genetics is a powerful approach based on chromosomal mapping of phenotypes and has successfu...
BACKGROUND: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been ...
Abstract Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome h...
Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been ...
Mice are extremely important as the premier model organism in human biomedical and mammalian genetic...
Abstract Background Allelic variation is the cornerstone of genetically determined differences in ge...
In our laboratory, we have focused on the behavioral diversity of wild derived mouse strains. A w...
The C57BL/6J (B6) inbred mouse strain is commonly used in biomedical researches. However, some unexp...
We sequenced the complete genome of the widely used C57L/J mouse inbred strain. With 40× average cov...
Since the turn of the century the complete genome sequence of just one mouse strain, C57BL/6J, has b...
Inbred mouse strains provide the foundation for mouse genetics. By selecting for phenotypic features...
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically...
Reverse genetics methods, particularly the production of gene knockouts and knockins, have revolutio...
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically...
Due to its rapid reproductive cycle, short life span and and genetic and physiological similarity to...
Forward genetics is a powerful approach based on chromosomal mapping of phenotypes and has successfu...