Abstract: Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cells is expected to serve as a basis for the development of novel therapies. Here we report on a new photopharmacological tool that enables manipulation of TRPC3 channels by light, in a manner independent of lipid metabolism and with higher temporal precision than lipid photopharmacology. Using the azobenzene photoswitch moiety, we modified GSK1702934A to generate light-controlled TRPC agonists. We obtained one light-sensitive molecule (OptoBI-1) that allows us to exert efficient, light-mediated control over TRPC3 activity and the associated cellular Ca2+ signaling. OptoBI-1...
International audienceIon channels are transmembrane proteins that control the movement of ions acro...
Remote control of physiological functions with light offers the promise of unveiling their complex s...
Optogenetics is a powerful research approach that allows localized optical modulation of selected ce...
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting prec...
Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly ga...
International audienceThe powerful optogenetic pharmacology method allows the optical control of neu...
Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but pl...
TRPC3 is one of the classical members of the mammalian transient receptor potential (TRP) superfamil...
Azobenzene-based photochromic lipids are valuable probes for the analysis of ion channel–lipid inter...
Chemo-optogenetics has produced powerful tools for optical control of cell activity, but current too...
International audienceLight-controllable tools provide powerful means to manipulate and interrogate ...
Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and a...
Drosophila phototransduction is a model for signaling cascades that culminate in the activation of t...
Caged compounds are biologically active molecules that are rendered inert by masking an important fu...
Optogenetics is a powerful research tool because it enables high-resolution optical control of neuro...
International audienceIon channels are transmembrane proteins that control the movement of ions acro...
Remote control of physiological functions with light offers the promise of unveiling their complex s...
Optogenetics is a powerful research approach that allows localized optical modulation of selected ce...
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting prec...
Summary: Small molecular probes designed for photopharmacology and opto-chemogenetics are rapidly ga...
International audienceThe powerful optogenetic pharmacology method allows the optical control of neu...
Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but pl...
TRPC3 is one of the classical members of the mammalian transient receptor potential (TRP) superfamil...
Azobenzene-based photochromic lipids are valuable probes for the analysis of ion channel–lipid inter...
Chemo-optogenetics has produced powerful tools for optical control of cell activity, but current too...
International audienceLight-controllable tools provide powerful means to manipulate and interrogate ...
Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and a...
Drosophila phototransduction is a model for signaling cascades that culminate in the activation of t...
Caged compounds are biologically active molecules that are rendered inert by masking an important fu...
Optogenetics is a powerful research tool because it enables high-resolution optical control of neuro...
International audienceIon channels are transmembrane proteins that control the movement of ions acro...
Remote control of physiological functions with light offers the promise of unveiling their complex s...
Optogenetics is a powerful research approach that allows localized optical modulation of selected ce...