Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.
- Cain, Amy K
- Boinett, Christine J
- Barquist, Lars
- Dordel, Janina
- Fookes, Maria
- Mayho, Matthew
- Ellington, Matthew J
- Goulding, David
- Pickard, Derek
- Wick, Ryan R
- Holt, Kathryn E
- Parkhill, Julian
- Thomson, Nicholas R
Publication date
June 2018
DOI Publisher
Springer Science and Business Media LLC Journal
Scientific ReportsAbstract
Colistin remains one of the few antibiotics effective against multi-drug resistant (MDR) hospital pathogens, such as Klebsiella pneumoniae. Yet resistance to this last-line drug is rapidly increasing. Characterized mechanisms of co
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