17β-Estradiol (E2), the most potent human estrogen, is known to be involved in the etiology of estrogen-dependent diseases (EDD) like breast cancer and endometriosis. 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyses the last step of E2 biosynthesis and is thus a promising target for the treatment of EDD. The previously described bicyclic substituted hydroxyphenylmethanones (BSHs) display high inhibitory potency towards human 17β-HSD1, but marginal activity towards rodent 17β-HSD1, precluding a proof of principle study in an animal endometriosis model. The aim of this work was to perform structural optimizations in the BSHs class to enhance inhibitory activity against rodent (mouse and rat) 17β-HSD1 while maintaining activity aga...
The human enzyme 17 beta-hydroxysteroid dehydrogenase 14 (17 beta-HSD14) oxidizes the hydroxyl group...
In search for specific drugs against steroid-dependent cancers we have developed a novel set of pote...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the last step of the estrogen biosynthe...
Estradiol is the most potent estrogen in humans. It is known to be involved in the development and p...
Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inh...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of estrone to estradiol, ...
<div><p>17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the developm...
17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into estrone. ...
ABSTRACT: 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into...
Members of the 17β-hydroxysteroid dehydrogenase (17β-HSD) superfamily perform distinct mul...
International audienceThe human enzyme 17b-hydroxysteroid dehydrogenase 14 (17b-HSD14) oxidizes the ...
Das Enzym 17β-Hydroxysteroid Dehydrogenase Typ 1 (17β-HSD1) katalysiert den letzten Schrit...
17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the development and ...
17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key role in...
Design and synthesis of a new class of inhibitors for the treatment of osteoporosis and its comparat...
The human enzyme 17 beta-hydroxysteroid dehydrogenase 14 (17 beta-HSD14) oxidizes the hydroxyl group...
In search for specific drugs against steroid-dependent cancers we have developed a novel set of pote...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the last step of the estrogen biosynthe...
Estradiol is the most potent estrogen in humans. It is known to be involved in the development and p...
Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inh...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of estrone to estradiol, ...
<div><p>17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the developm...
17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into estrone. ...
ABSTRACT: 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into...
Members of the 17β-hydroxysteroid dehydrogenase (17β-HSD) superfamily perform distinct mul...
International audienceThe human enzyme 17b-hydroxysteroid dehydrogenase 14 (17b-HSD14) oxidizes the ...
Das Enzym 17β-Hydroxysteroid Dehydrogenase Typ 1 (17β-HSD1) katalysiert den letzten Schrit...
17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the development and ...
17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key role in...
Design and synthesis of a new class of inhibitors for the treatment of osteoporosis and its comparat...
The human enzyme 17 beta-hydroxysteroid dehydrogenase 14 (17 beta-HSD14) oxidizes the hydroxyl group...
In search for specific drugs against steroid-dependent cancers we have developed a novel set of pote...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the last step of the estrogen biosynthe...