Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.
- Koutsoudakis, George
- Romero-Brey, Inés
- Berger, Carola
- Pérez-Vilaró, Gemma
- Monteiro Perin, Paula
- Vondran, Florian Wolfgang Rudolf
- Kalesse, Markus
- Harmrolfs, Kirsten
- Müller, Rolf
- Martinez, Javier P
- Pietschmann, Thomas
- Bartenschlager, Ralf
- Brönstrup, Mark
- Meyerhans, Andreas
- Díez, Juana
DOIAbstract
Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human immunodeficiency virus (HIV). The aim of the present study was to evaluate the capacity of SorA and analogues to inhibit hepatitis C virus (HCV) infection
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