Abstract Background The deciphering of cellular networks to determine susceptibility to infection by HIV or the related simian immunodeficiency virus (SIV) is a major challenge in infection biology. Results Here, we have compared gene expression profiles of a human CD4+ T cell line at 24 h after infection with a cell line of the same origin permanently releasing SIVmac. A new knowledge-based-network approach (Inter-Chain-Finder, ICF) has been used to identify sub-networks associated with cell survival of a chronically SIV-infected T cell line. Notably, the method can identify not only differentially expressed key hub genes but also non-differentially expressed, critical, ‘hidden’ regulators. Six out of the 13 predicted major hidden key regu...
<div><p>Immune response genes play an important role during acute HIV and SIV infection. Using an SI...
Changes in T-cell function are a hallmark of human immunodeficiency virus type 1 (HIV-1) infection, ...
HIV infection affects the populations of T helper cells, dendritic cells and macrophages. Moreover, ...
BACKGROUND: The deciphering of cellular networks to determine susceptibility to infection by HIV or ...
The deciphering of cellular networks to determine susceptibility to infection by HIV or the related ...
To gain insights into the molecular mechanisms underlying early host responses to HIV in the CD4(+) ...
BACKGROUND: The National Institute of Allergy and Infectious Diseases has launched the HIV-1 Human P...
The acquired immunodeficiency syndrome (AIDS) is a clinically multifaceted disease induced by infect...
Background: Downregulation of the CD4 receptor is one of the hallmarks of HIV infection. The virus h...
Lymphoid tissues (LTs) are the principal sites where human immunodeficiency virus type 1 (HIV-1) rep...
Fig.1. HIV-1 infection of SupT1 cells. A) Bright and fluorescent microscopic examinations of HEK293T...
T follicular helper (Tfh) cells were thought to be resistant to HIV-1 infection because of absent CC...
<p>(<b>A</b>) Fold change scatterplot comparing gene expression between HIV T (+DC) (CD4<sup>+</sup>...
Human immunodeficiency virus infection is a chronic condition causing significant changes in the imm...
AbstractThe gene expression profile of the HIV-1 infection state was analyzed in the human T cell li...
<div><p>Immune response genes play an important role during acute HIV and SIV infection. Using an SI...
Changes in T-cell function are a hallmark of human immunodeficiency virus type 1 (HIV-1) infection, ...
HIV infection affects the populations of T helper cells, dendritic cells and macrophages. Moreover, ...
BACKGROUND: The deciphering of cellular networks to determine susceptibility to infection by HIV or ...
The deciphering of cellular networks to determine susceptibility to infection by HIV or the related ...
To gain insights into the molecular mechanisms underlying early host responses to HIV in the CD4(+) ...
BACKGROUND: The National Institute of Allergy and Infectious Diseases has launched the HIV-1 Human P...
The acquired immunodeficiency syndrome (AIDS) is a clinically multifaceted disease induced by infect...
Background: Downregulation of the CD4 receptor is one of the hallmarks of HIV infection. The virus h...
Lymphoid tissues (LTs) are the principal sites where human immunodeficiency virus type 1 (HIV-1) rep...
Fig.1. HIV-1 infection of SupT1 cells. A) Bright and fluorescent microscopic examinations of HEK293T...
T follicular helper (Tfh) cells were thought to be resistant to HIV-1 infection because of absent CC...
<p>(<b>A</b>) Fold change scatterplot comparing gene expression between HIV T (+DC) (CD4<sup>+</sup>...
Human immunodeficiency virus infection is a chronic condition causing significant changes in the imm...
AbstractThe gene expression profile of the HIV-1 infection state was analyzed in the human T cell li...
<div><p>Immune response genes play an important role during acute HIV and SIV infection. Using an SI...
Changes in T-cell function are a hallmark of human immunodeficiency virus type 1 (HIV-1) infection, ...
HIV infection affects the populations of T helper cells, dendritic cells and macrophages. Moreover, ...