Estradiol is the most potent estrogen in humans. It is known to be involved in the development and proliferation of estrogen dependent diseases such as breast cancer and endometriosis. The last step of its biosynthesis is catalyzed by 17β-hydroxysteroid dehydrogenase type 1 (17β- HSD1) which consequently is a promising target for the treatment of these diseases. Recently, we reported on bicyclic substituted hydroxyphenylmethanones as potent inhibitors of 17β-HSD1. The present study focuses on rational structural modifications in this compound class with the aim of gaining more insight into its structure-activity relationship (SAR). (4-Hydroxyphenyl)-(5-(3-hydroxyphenylsulfanyl)-thiophen-2-yl)methanone (25) was discovered as a member of a no...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the last step of the estrogen biosynthe...
The high expression of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) mRNA has been found in bre...
17b-Hydroxysteroid dehydrogenase type 1 (17b-HSD1) is a key enzyme in the biosynthesis of 17b-estrad...
17β-Estradiol (E2), the most potent human estrogen, is known to be involved in the etiology of estro...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of estrone to estradiol, ...
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the potent estrogen estradiol into the w...
International audienceThe human enzyme 17b-hydroxysteroid dehydrogenase 14 (17b-HSD14) oxidizes the ...
Members of the 17β-hydroxysteroid dehydrogenase (17β-HSD) superfamily perform distinct mul...
In search for specific drugs against steroid-dependent cancers we have developed a novel set of pote...
<div><p>17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the developm...
17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into estrone. ...
17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the development and ...
ABSTRACT: 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into...
17β-HSD14 belongs to the SDR family and oxidizes the hydroxyl group at position 17 of estradiol and ...
The human enzyme 17 beta-hydroxysteroid dehydrogenase 14 (17 beta-HSD14) oxidizes the hydroxyl group...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the last step of the estrogen biosynthe...
The high expression of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) mRNA has been found in bre...
17b-Hydroxysteroid dehydrogenase type 1 (17b-HSD1) is a key enzyme in the biosynthesis of 17b-estrad...
17β-Estradiol (E2), the most potent human estrogen, is known to be involved in the etiology of estro...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the reduction of estrone to estradiol, ...
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the potent estrogen estradiol into the w...
International audienceThe human enzyme 17b-hydroxysteroid dehydrogenase 14 (17b-HSD14) oxidizes the ...
Members of the 17β-hydroxysteroid dehydrogenase (17β-HSD) superfamily perform distinct mul...
In search for specific drugs against steroid-dependent cancers we have developed a novel set of pote...
<div><p>17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the developm...
17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into estrone. ...
17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the development and ...
ABSTRACT: 17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) catalyzes the inactivation of estradiol into...
17β-HSD14 belongs to the SDR family and oxidizes the hydroxyl group at position 17 of estradiol and ...
The human enzyme 17 beta-hydroxysteroid dehydrogenase 14 (17 beta-HSD14) oxidizes the hydroxyl group...
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the last step of the estrogen biosynthe...
The high expression of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) mRNA has been found in bre...
17b-Hydroxysteroid dehydrogenase type 1 (17b-HSD1) is a key enzyme in the biosynthesis of 17b-estrad...