International audienceBrain microvascular endothelial cells (BMECs) interact with astrocytes and pericytes to form the blood–brain barrier (BBB). Their compromised function alters the BBB integrity, which is associated with early events in the pathogenesis of cancer, neurodegenerative diseases, and epilepsy. Interestingly, these conditions also induce the expression of heat shock proteins (HSPs). Here we review the contribution of major HSP families to BMEC and BBB function. Although investigators mainly report protective effects of HSPs in brain, contrasted results were obtained in BMEC, which depend both on the HSP and on its location, intra- or extracellular. The therapeutic potential of HSPs must be scrupulously analyzed before targetin...
Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). W...
Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders,...
The work presented in this thesis investigates the protective effects of the heat shock proteins in ...
We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the b...
The damage borne by the endothelial cells (ECs) forming the blood-brain barrier (BBB) during ischemi...
Heat shock proteins (Hsps) are induced by heat shock via heat shock factor proteins binding to heat ...
Heat shock proteins (HSPs) are families of molecular chaperones that play important homeostatic func...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
Inflammation within the central nervous system often accompanies ischemia, trauma, infection, and ot...
The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological b...
Stress proteins or heat shock proteins (HSPs) are ubiquitous cellular components that have long been...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which...
Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural s...
The blood–brain barrier (BBB) controls brain access of molecules and cells, communicates immune stat...
Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). W...
Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders,...
The work presented in this thesis investigates the protective effects of the heat shock proteins in ...
We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the b...
The damage borne by the endothelial cells (ECs) forming the blood-brain barrier (BBB) during ischemi...
Heat shock proteins (Hsps) are induced by heat shock via heat shock factor proteins binding to heat ...
Heat shock proteins (HSPs) are families of molecular chaperones that play important homeostatic func...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
Inflammation within the central nervous system often accompanies ischemia, trauma, infection, and ot...
The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological b...
Stress proteins or heat shock proteins (HSPs) are ubiquitous cellular components that have long been...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which...
Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural s...
The blood–brain barrier (BBB) controls brain access of molecules and cells, communicates immune stat...
Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). W...
Cortical spreading depression (CSD) is a pathophysiological mechanism underlying headache disorders,...
The work presented in this thesis investigates the protective effects of the heat shock proteins in ...