Increasing contribution of integrated forms to total HIV DNA in blood during HIV disease progression from primary infection
- Trémeaux, Pauline
- Lenfant, Tiphaine
- Boufassa, Faroudy
- Essat, Asma
- Mélard, Adeline
- Gousset, Marine
- Delelis, Olivier
- Viard, Jean-Paul
- Bary, Marc
- Goujard, Cecile
- Rouzioux, Christine
- Meyer, Laurence
- Avettand-Fenoel, Véronique
DOIAbstract
International audienceBACKGROUND:In the current context of research on HIV reservoirs, offering new insights into the persistence of HIV DNA in infected cells, which prevents viral eradication, may aid in identifying cure strategies. This study aimed to describe the establishment of stable integrated forms among total HIV DNA during primary infection (PHI) and their dynamics during the natural history of infection.METHODS:Total and integrated HIV DNA were quantified in blood from 74 PHI patients and 97 recent seroconverters (<12 months following infection, "progression cohort"). The evolution of both markers over six years was modelled (mixed-effect linear models). Their predictive values for disease progression were studied (Cox models).FI...
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