International audienceThe chemical composition of protostellar jets and its origin are still badly understood. More observational constraints are needed to make progress. With that objective, we have carried out a systematic search for molecular species in the jet of Cep E-mm, a template for intermediate-mass Class 0 protostars, associated with a luminous, high-velocity outflow. We made use of an unbiased spectral line survey in the range 72-350 GHz obtained with the IRAM 30m telescope, complementary observations of the CO J=3-2 transition with the JCMT, and observations at 1 ′′ angular resolution of the CO J=2-1 transition with the IRAM Plateau de Bure interferometer. In addition to CO, we have detected rotational transitions from SiO, SO,...