Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α
- Dai, Yan
- Liu, Ruijie
- Chen, Anqun
- Gu, Leyi
- Sharma, Shuchita
- Cai, Weijing
- Salem, Fadi
- Salant, David, J
- Pippin, Jeffrey
- Shankland, Stuart
- Moeller, Marcus, J
- Ghyselinck, Norbert B
- Ding, Xiaquiang
- Chuang, Peter, y
- Lee, Kyung
- Cijiang He, John
DOIAbstract
International audienceProliferation of glomerular epithelial cells, including the podocytes, is a key histologic feature of crescentic glomerulonephritis. We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating RA receptor-α (RARα) in a murine model of HIV-associated nephropathy. Here, we examined whether RA would similarly protect podocyte
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