Cross-linked hyaluronan films loaded with acetazolamide-cyclodextrin-triethanolamine complexes for glaucoma treatment
- Calles, Javier Adrián
- Mora, Maria Julia
- Onnainty, Renée
- Tartara, Luis Ignacio
- Granero, Gladys Ester
- Longhi, Marcela Raquel
- Diebold Luque, Yolanda
- Valles, Enrique Marcelo
- Palma, Santiago Daniel
DOIAbstract
This work aimed to design and characterize cross-linked hyaluronic acid-itaconic acid films loaded with acetazolamide-hydroxypropyl β cyclodextrin-triethanolamine complexes. Materials & methods: Films were cross-linked with itaconic acid and poly(ethyleneglycol)-diglycidylether. Biopharmaceutical properties were assessed by evaluating in vitro drug release rate, biocompatibility in a human corneal epithelial cell line, bioadhesiveness with pig gastric mucin, in vivo bioadhesion and efficacy. Results: Showed good mechanical properties and oxygen permeability. Proliferation rate of corneal cells was affected by highest acetazolamide concentration. Bioadhesive interaction exhibited a water movement from pig mucin to the film; in vivo experimen...
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