Synthesis of triazole derivatives of levoglucosenone as promising anticancer agents: Effective exploration of the chemical space through retro-za-michael//aza-michael isomerizations
- Tsai, Yi Hsuan
- Borini Etichetti, Carla Maria
- Di Benedetto, Carolina
- Girardini Brovelli, Javier Enrique
- Martins, Felipe Terra
- Spanevello, Rolando Angel
- Suarez, Alejandra Graciela
- Sarotti, Ariel Marcelo
DOIAbstract
The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents are described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted 1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.Fil: Tsai, Yi Hsuan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: B...
Add to ORKG