Effects of quercetin on heart nitric oxide metabolism in L-NAME treated rats
- Calabró López, María Valeria
- Litterio, Maria Corina
- Fraga, César Guillermo
- Galleano, Mónica Liliana
- Piotrkowski, Barbara
DOIAbstract
This study investigated the effects of a quercetin-supplemented diet on the biochemical changes installed in the heart of NO-deficient rats in terms of oxidants production and NO bioavailability determinants. Sprague-Dawley rats were subjected to Nω-nitro-L-arginine methyl ester (L-NAME) treatment (360 mg/L L-NAME in the drinking water, 4 d) with or without supplementation with quercetin (4 g/kg diet). L-NAME administration led to increased blood pressure (BP) (30%), decreased nitric oxide synthase (NOS) activity (50%), and increases in NADPH oxidase (NOX)-dependent superoxide anion production (60%) and p47phox protein level (65%). The co-administration of quercetin prevented the increase in BP and the activation of NOX but did not modify t...
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