Regulating "ring rate of networks of pyramidal cells

In a minimal network model consisting of two pyramidal cells and one interneuron, we show how excitation and inhibition cooperate to produce "ring rate changes in pyramidal cells that are consistent with observed place cell "ring in region CA3 of the hippocampus. We show that inhibition from a common interneuron can synchronize networks of pyramidal cells with no direct connections. Moreover, recurrent excitation together with common inhibition can modulate burst pro"les of synchronously "ring cells from complex bursts to bursts with multiple spike to single spikes. � 2001 Elsevier Science B.V. All rights reserved