Laminar Optical Tomography (LOT) is an optical imaging technique capable of imaging absorption and fluorescence contrast in-vivo to depths of>2mm with 100-200 micron resolution. LOT has been used to image the living brain in experiments to investigate the hemodynamic response in rat cortex during forepaw stimulus. We show that using LOT, it is possible to resolve the contributions of each vascular compartment to the ensemble hemodynamic response. The LOT system will be described and its future application to other areas of medical imaging will be discussed. 1
We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier doma...
The microvasculature is the network of blood vessels involved in delivering nutrients and gases nece...
Optical imaging of cerebral hemodynamics has been used extensively to investigate the complex interp...
Laminar optical tomography (LOT) is an optical imaging technique capable of making depth-resolved me...
This thesis describes experiments and analyses which push the frontier per what one can learn from o...
Technological advances in image acquisition speeds and new contrast agents, in both clinical and bas...
Visualizing high-resolution hemodynamics in cerebral tissue over a large field-of view (FOV), provid...
[[abstract]]Understanding how the brain functions is one of the grand challenges in modern scientifi...
Optical techniques already have an important place in experimental in vivo studies of the brain. New...
Background—Optical coherence tomo-graphy (OCT) is a new method of catheter based micron scale imagin...
textBlood flow and its payload of molecular oxygen are two parameters of most physiological interest...
Laminar optical tomography (LOT) is a mesoscopic three-dimensional (3D) optical imaging technique th...
In vivo (molecular) imaging of the vessel wall of large arteries at subcellular resolution is crucia...
In this report we present a brief outline of our technological approaches to developing a comprehens...
Introduction: The hemodynamic response following neural activation is the basis for most functional ...
We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier doma...
The microvasculature is the network of blood vessels involved in delivering nutrients and gases nece...
Optical imaging of cerebral hemodynamics has been used extensively to investigate the complex interp...
Laminar optical tomography (LOT) is an optical imaging technique capable of making depth-resolved me...
This thesis describes experiments and analyses which push the frontier per what one can learn from o...
Technological advances in image acquisition speeds and new contrast agents, in both clinical and bas...
Visualizing high-resolution hemodynamics in cerebral tissue over a large field-of view (FOV), provid...
[[abstract]]Understanding how the brain functions is one of the grand challenges in modern scientifi...
Optical techniques already have an important place in experimental in vivo studies of the brain. New...
Background—Optical coherence tomo-graphy (OCT) is a new method of catheter based micron scale imagin...
textBlood flow and its payload of molecular oxygen are two parameters of most physiological interest...
Laminar optical tomography (LOT) is a mesoscopic three-dimensional (3D) optical imaging technique th...
In vivo (molecular) imaging of the vessel wall of large arteries at subcellular resolution is crucia...
In this report we present a brief outline of our technological approaches to developing a comprehens...
Introduction: The hemodynamic response following neural activation is the basis for most functional ...
We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier doma...
The microvasculature is the network of blood vessels involved in delivering nutrients and gases nece...
Optical imaging of cerebral hemodynamics has been used extensively to investigate the complex interp...