In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we show that the glucocorticoid hormone analog dexamethasone induces circadian gene expression in cultured rat-1 fibroblasts and transiently changes the phase of circadian gene expression in liver, kidney, and heart. However, dexamethasone does not affect cyclic gene expression in neurons of the suprachiasmatic nucleus. This enabled us to establish an apparent phase-shift response curve specifically for peripheral clocks in intact animals. In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throug...
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; howeve...
Glucocorticoids, hormones produced by the adrenal gland cortex, exert numerous functions in body hom...
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; howeve...
In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which harbors the c...
Peripheral clocks are set by different nervous, hormonal and metabolic stimuli, and regulate the cir...
Circulating cortisol fluctuates diurnally under the control of the "master" circadian CLOCK, while t...
Circulating cortisol fluctuates diurnally under the control of the “master” circadian CLOCK, while t...
Context and Objective: Circulating cortisol fluctuates diurnally under the control of the ‘‘master’ ...
In mammals, all overt circadian rhythms are thought to be coordinated by a central pacemaker residin...
Glucocorticoids are mammalian steroid hormones secreted from the adrenal gland. The basal levels of ...
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadi...
In mammals, circadian rhythms of physiology and behavior are regulated by a complex network of cellu...
SummaryIn mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found...
Circadian clocks control many vital aspects of physiology from the sleep-wake cycle to metabolism. T...
Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stre...
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; howeve...
Glucocorticoids, hormones produced by the adrenal gland cortex, exert numerous functions in body hom...
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; howeve...
In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which harbors the c...
Peripheral clocks are set by different nervous, hormonal and metabolic stimuli, and regulate the cir...
Circulating cortisol fluctuates diurnally under the control of the "master" circadian CLOCK, while t...
Circulating cortisol fluctuates diurnally under the control of the “master” circadian CLOCK, while t...
Context and Objective: Circulating cortisol fluctuates diurnally under the control of the ‘‘master’ ...
In mammals, all overt circadian rhythms are thought to be coordinated by a central pacemaker residin...
Glucocorticoids are mammalian steroid hormones secreted from the adrenal gland. The basal levels of ...
Total glucocorticoid hormone levels in plasma of various species, including humans, follow a circadi...
In mammals, circadian rhythms of physiology and behavior are regulated by a complex network of cellu...
SummaryIn mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks found...
Circadian clocks control many vital aspects of physiology from the sleep-wake cycle to metabolism. T...
Glucocorticoids are steroid hormones of the adrenal gland that are an integral component of the stre...
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; howeve...
Glucocorticoids, hormones produced by the adrenal gland cortex, exert numerous functions in body hom...
The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; howeve...