MINIREVIEW Searching for folded proteins in vitro and in silico

Understanding the sequence determinants of protein structure, stabilityand folding is critical for understanding how natural proteins have evolved and how proteins can be engineered to perform novel functions. The complexityof the protein folding problem requires the abilityto search large volumes of sequence space for proteins with specific structural or functional characteristics. Here we describe our efforts to identifynovel proteins using a phage-displa