High Performance Biosequence Database Scanning on Reconfigurable Platforms

Molecular biologists frequently compare an unknown protein sequence with a set of other known sequences (a database scan) to detect functional similarities. Even though efficient dynamic programming algorithms exist for the problem, the required scanning time is still very high, and because of the rapid database growth finding fast solutions is of highest importance to research in this area. In this paper we present a new approach to biosequence database scanning on reconfigurable hardware platforms to gain high performance at low cost. To derive an efficient mapping onto this type of architecture, we have designed fine-grained parallel processing elements (PEs). Since our solution is based on reconfigurable hardware, we can design PEs that are tailored towards the parameters of a query. This results in an implementation with significant runtime savings on a standard off-the-shelf FPGA. 1