Abstract. Let k be an algebraically closed field of characteristic 0. We prove that any division algebra over k(x, y) whose ramification locus lies on a quartic curve is cyclic. 1. Main result Let k be an algebraically closed field of characteristic 0, L = k(x,y) its purely transcendental extension of degree 2. We are interested in division L-algebras with ramification only at a quartic curve. Our main result (Theorem 1.2), which grew out from our earlier paper [11], shows that any such algebra is a symbol algebra whose index equals the exponent. This is a generalization of earlier results of Ford, Van den Bergh and Jacob on cyclicity of k(x,y)-algebras ramified either along a cubic curve, or a hyperelliptic curve, or a special quartic curv...