Nuclear Hormone Receptor NHR-49

e novel insights into how NHR regulatory networks are coordinated to govern fat metabolism. Citation: Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3(2): e53. Introduction Due to their ability to interact with fatty acids and other lipids, nuclear hormone receptors (NHRs), including peroxisome proliferator-activated receptors (PPARs), liver X receptor, and farnesoid X receptor, are important regulators of mammalian fat metabolism; accordingly, these smallmolecule -gated transcription factors have been favored targets for therapies designed to combat diabetes, obesity, and atherosclerosis [1,2,3]. Although the molecular mechanisms employed by NHRs have been intensively probed, their pleiotropic effects on overall animal physiology are only partially understood. Thus, developing a broader range of experimental systems would be useful for characterizing the fat re