Simultaneous Registration and Activation Detection: Overcoming Activation-Induced Registration Errors in Functional MRI

In the processing of functional magnetic resonance imaging (fMRI) data, motion correction is typically performed before activation detection. However, on high-field MR scanners (3 T and higher), the strength of the blood oxygen level dependent (BOLD) signal can cause registration algorithms to produce motion estimates that have stimulus-correlated errors. Motion compensation using these biased motion estimates can result in both false-positive and false-negative regions of activation