Generic Properties Of The Sequence-Structure Relations Of Biopolymers

ntaining all ff n possible genotypes of given chain length n, where ff denotes the size of the polynucleotide or amino acid alphabet. Distances in sequence space are expressed by the minimum number of single nucleotide exchanges or point mutations 2 PETER F. STADLER SEQUENCE SPACE SHAPE SPACE PARAMETER SPACE (Fitness Values) CONCENTRATIION SPACE Population Dynamics Support Dynamics the environment evaluation by folding, morphogenesis Figure 1. Evolutionary dynamics. In vitro evolution of biomolecules is partitioned into four components: (i) population dynamics, (ii) population support dynamics, (iii) genotype -phenotype mapping, and (iv) evaluation of the phenotype. Wright's notion of a fitness landscape is the composite of genotype-phenotype mapping and phenotype evaluation (shaded in gray). Population dynamics is tantamount to chemical reactio