Random graph theory is used to model relationships between sequences and secondary structures of RNA molecules. Sequences folding into identical structures form neutral networks which percolate sequence space if the fraction of neutral nearest neighbors exceeds a threshold value. The networks of any two different structures almost touch each other, and sequences folding into almost all "common" structures can be found in a small ball of an arbitrary location in sequence space. The results from random graph theory are compared with data obtained by folding large samples of RNA sequences. Differences are explained in terms of RNA molecular structures. 1. Introduction Conventional biophysics is concerned with structure predictions of...
Algorithms predicting RNA secondary structures based on different folding criteria -- minimum free e...
In this paper recent results on random graphs are used as a framework for a theory of mutation based...
Abstract: An introduction into the usage of graph or network theory tools for the study of RNA molec...
In this paper the authors investigate the evolution of molecular structures by random point mutation...
Grüner W, Giegerich R, Strothmann D, et al. Analysis of RNA sequence structure maps by exhaustive en...
Searching for biopolymers having a predefined function is a core problem of biotechnology, biochemis...
Searching for biopolymers having a predefined function is a core problem of biotechnology, biochemis...
The evolution and adaptation of molecular populations is constrained by the diversity accessible thr...
Global properties of the genotype-phenotype map induced by RNA secondary structures can be described...
Grüner W, Giegerich R, Strothmann D, et al. Analysis of RNA sequence structure maps by exhaustive en...
Secondary structures of nucleic acids are a particularly interesting class of contact structures. Ma...
Understanding of structure-function mapping is crucial to the study of the nature of biopolymers. Th...
Background: The analysis of sequence-structure relations of RNA is based on a specific notion and fo...
In this paper the authors consider the evolutionary dynamics of populations of sequences, under a pr...
<p>Additional properties of the <i>l</i> = 12 RNA neutral networks space can be found in <a href="ht...
Algorithms predicting RNA secondary structures based on different folding criteria -- minimum free e...
In this paper recent results on random graphs are used as a framework for a theory of mutation based...
Abstract: An introduction into the usage of graph or network theory tools for the study of RNA molec...
In this paper the authors investigate the evolution of molecular structures by random point mutation...
Grüner W, Giegerich R, Strothmann D, et al. Analysis of RNA sequence structure maps by exhaustive en...
Searching for biopolymers having a predefined function is a core problem of biotechnology, biochemis...
Searching for biopolymers having a predefined function is a core problem of biotechnology, biochemis...
The evolution and adaptation of molecular populations is constrained by the diversity accessible thr...
Global properties of the genotype-phenotype map induced by RNA secondary structures can be described...
Grüner W, Giegerich R, Strothmann D, et al. Analysis of RNA sequence structure maps by exhaustive en...
Secondary structures of nucleic acids are a particularly interesting class of contact structures. Ma...
Understanding of structure-function mapping is crucial to the study of the nature of biopolymers. Th...
Background: The analysis of sequence-structure relations of RNA is based on a specific notion and fo...
In this paper the authors consider the evolutionary dynamics of populations of sequences, under a pr...
<p>Additional properties of the <i>l</i> = 12 RNA neutral networks space can be found in <a href="ht...
Algorithms predicting RNA secondary structures based on different folding criteria -- minimum free e...
In this paper recent results on random graphs are used as a framework for a theory of mutation based...
Abstract: An introduction into the usage of graph or network theory tools for the study of RNA molec...