Genetic Sequence Annotation within Biological Databases

Biological data description is an essential stage after the result acquisition by biologists during their experiments. This phase must be done with a maximum consistency and standardization between biologists and biological databases and their staffs, in order to take advantage of data in these data structures.We developed a methodology of achieving a semi-automatic biological sequence annotation which respects usual steps of software engineering (conception, specifications, programming and validation protocol). This work is inscribed in the more general context of an interactive system for database in immunogenetics [1]. The sequences to be annotated are extracted from files from the generalist nucleic sequence data bank EMBL 1 and the annotations after validation are directly integrated in the specialized database [2]. 1 Introduction The rise of techniques in molecular biology in the 1970s-1980s, in particular the rapid advance of sequencing technology (specially the development o..