. We propose a biochemically plausible mechanism for constructing digital logic signals and gates of significant complexity within living cells. These mechanisms rely largely on co-opting existing biochemical machinery and binding proteins found naturally within the cell, replacing difficult protein engineering problems with more straightforward engineering of novel combinations of gene control sequences and gene coding regions. The resulting logic technology, although slow, allows us to engineer the chemical behavior of cells for use as sensors and effectors. One promising use of such technology is the control of fabrication processes at the molecular scale. 1 Introduction Cells provide an isolated, controlled environment for carrying out...
Cells navigate environments, communicate and build complex patterns by initiating gene expression in...
Society for Analytical Chemists of Pittsburgh; National Instrumentation Program (NIP) of China; Nati...
Biological organisms use complex molecular networks to navigate their environment and regulate their...
A Scientist discovers that which exists. An Engineer creates that which never was. Theodore von Karm...
We propose a biochemically plausible mechanism for constructing digital logic signals and gates of s...
It appears that biological organisms can be harnessed as substrates for computation. Biological cell...
A central aim of synthetic biology is to build organisms that can perform useful activities in respo...
Biological organisms use complex molecular networks to navigate their environment and regulate their...
Synthetic engineering methods, such as DNA computation and unnatural amino acid mutagenesis, have pr...
Researchers increasingly envision an important role for artificial biochemical circuits in biologica...
Gene regulatory networks lay at the foundation of biological function and are responsible for drivin...
Microorganisms are able to respond effectively to diverse signals from their environment and interna...
A negating functionality is fundamental to information processing of logic circuits within cells and...
Ongoing efforts within synthetic and systems biology have been directed towards the building of arti...
ver the next few decades, two emerg-ing technologies—microfabrication and cellular engineering—will ...
Cells navigate environments, communicate and build complex patterns by initiating gene expression in...
Society for Analytical Chemists of Pittsburgh; National Instrumentation Program (NIP) of China; Nati...
Biological organisms use complex molecular networks to navigate their environment and regulate their...
A Scientist discovers that which exists. An Engineer creates that which never was. Theodore von Karm...
We propose a biochemically plausible mechanism for constructing digital logic signals and gates of s...
It appears that biological organisms can be harnessed as substrates for computation. Biological cell...
A central aim of synthetic biology is to build organisms that can perform useful activities in respo...
Biological organisms use complex molecular networks to navigate their environment and regulate their...
Synthetic engineering methods, such as DNA computation and unnatural amino acid mutagenesis, have pr...
Researchers increasingly envision an important role for artificial biochemical circuits in biologica...
Gene regulatory networks lay at the foundation of biological function and are responsible for drivin...
Microorganisms are able to respond effectively to diverse signals from their environment and interna...
A negating functionality is fundamental to information processing of logic circuits within cells and...
Ongoing efforts within synthetic and systems biology have been directed towards the building of arti...
ver the next few decades, two emerg-ing technologies—microfabrication and cellular engineering—will ...
Cells navigate environments, communicate and build complex patterns by initiating gene expression in...
Society for Analytical Chemists of Pittsburgh; National Instrumentation Program (NIP) of China; Nati...
Biological organisms use complex molecular networks to navigate their environment and regulate their...