The search for a general semantic characterization of sequential functions is motivated by the full abstraction problem for sequential programming languages such as PCF. We present here some new developments towards such a theory of sequentiality. We give a general definition of sequential functions on Scott domains, characterized by means of a generalized form of topology, based on sequential open sets. Our notion of sequential function coincides with the Kahn-Plotkin notion of sequential function when restricted to distributive concrete domains, and considerably expands the class of domains for which sequential functions may be defined. We show that the sequential functions between two dI-domains, ordered stably, form a dI-domain. The ana...